Munson Health
Zollinger-Ellison Syndrome

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by Scheinberg D

(Z-E Syndrome; Gastrinoma)



Symptoms may include:
  • Abdominal pain
  • Heartburn
  • Nausea or vomiting
  • Fatigue
  • Diarrhea
  • Weight loss
  • Blood in the vomit or stool


American Gastroenterological Association

National Digestive Diseases Information Clearinghouse



The Canadian Association of Gastroenterology

Health Canada



Berna MJ, Hoffmann KM, et al. Serum gastrin in Zollinger-Ellison syndrome: II. Prospective study of gastrin provocative testing in 293 patients from the National institutes of Health and comparison with 537 cases from the literature, evaluation of diagnostic criteria, proposal of new criteria, and correlations with clinical and tumoral features. Medicine. 2006;85:331-364.

Campana D, Piscitelli L, et al. Zollinger-Ellison syndrome: diagnosis and therapy. Minerva Med. 2005;96:167-206.

Norton JA, Fraker DL, et al. Surgery to cure the Zollinger-Ellison syndrome. N Engl J Med. 1999;341:635-644.

Norton JA, Jensen RT. Resolved and unresolved controversies in the surgical management of patients with Zollinger-Ellison Syndrome. Ann Surg. 2004;240:757-773.

Tomassetti P, Salomone T, et al. Optimal treatment of Zollinger-Ellison syndrome and related conditions in elderly patients. Drgus Aging. 2003;20:1019-1034.

Zollinger-Ellison syndrome. EBSCO DynaMed website. Available at: Updated March 5, 2013. Accessed August 1, 2013.

Zollinger-Ellison syndrome. National Digestive Diseases Information Clearinghouse website. Available at: Updated May 10, 2012. Accessed August 1, 2013.


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