Munson Health
 
Acute Tubular Necrosis

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by McCoy K
 

Risk Factors

A risk factor is something that increases your chance for getting a disease or condition. Risk factors that increase your chance of developing acute tubular necrosis include:
  • Injury
  • Trauma (Injury or trauma that damages the muscles)
  • Surgery
  • Blood transfusion
  • Septic shock
  • Shock
  • Low blood pressure
  • Liver disease or damage
  • Drugs (aminoglycosides, amphotericin B, cyclosporine, tacrolimus)
  • X-ray dye
  • Blood transfusion reaction
  • Toxic chemicals: This list is things produced by the body, maybe we also need to discuss toxic chemicals from elsewhere
    • Crystals (uric acid, calcium phosphate)
    • Myoglobin
    • Hemaglobin
 

Treatment

Talk with your doctor about the best treatment plan for you. In addition to good nutritional support and fluid , treating underlying condition, dietary changes, treatment options include the following:

Dialysis

Dialysis , in which a machine does the work of your kidneys by purging waste from your body.

Medications

Certain medications (eg, furosemide, bumetanide, mannitol, fenoldopam, auriculin anaritide, and synthetic atrial natriuretic peptide) may reduce the need for dialysis in certain people with acute tubular necrosis.
 

RESOURCES

American Academy of Family Physicians
http://familydoctor.org

National Kidney and Urologic Diseases Information Clearinghouse
http://kidney.niddk.nih.gov

 

CANADIAN RESOURCES

Canadian Institute for Health Information
http://www.cihi.ca

Kidney Foundation of Canada
http://www.kidney.ca

 

References


Acute tubular necrosis. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed . Updated June 14, 2010. Accessed November 1, 2012.


Choudhury D, Ahmed Z: Drug-associated renal dysfunction and injury. Nat Clin Pract Nephrol . 2006;2:80-91


Esson ML, Schrier RW. Diagnosis and treatment of acute tubular necrosis. Ann Intern Med . 2002;137:744-52.


Gill N, Nally JV Jr, Fatica RA. Renal failure secondary to acute tubular necrosis: epidemiology, diagnosis, and management. Chest . 2005;128:2847-2863.


Musso CG, Liakopoulos V, Ioannidis I, et al. Acute renal failure in the elderly: particular characteristics. Int Urol Nephrol . 2006;38:787-93


Tepel M, van der Giet M, Schwarzfeld C, et al. Prevention of radiographic-contrast reductions in renal function by acetylcysteine. N Engl J Med . 2000;343:1448-1457.

 

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