Munson Health
 
Acromegaly

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by Alan R
 

Causes

The pituitary gland is a small gland located at the base of the brain. It produces many hormones, including GH.
In most cases, the elevation of GH is caused by a benign tumor of this gland. In a small number of cases, cancerous tumors of other organs, such as the pancreas, adrenal, or lung, may be the source of excess GH.
Pituitary Gland
Nucleus factsheet image
Copyright © Nucleus Medical Media, Inc.
 

Symptoms

Symptoms usually develop slowly over time.
In children, the bones are longer and cause soft tissue swelling. If not treated, children can grow to a height of 7-8 feet.
Symptoms and complications in adults may include:
 

RESOURCES

National Institute of Diabetes & Digestive & Kidney Diseases
http://www.niddk.nih.gov

Pituitary Network Association
http://www.pituitary.org

 

CANADIAN RESOURCES

Canadian Society of Endocrinology and Metabolism
http://www.endo-metab.ca

Health Canada
http://www.hc-sc.gc.ca

 

References


Abrams P, Alexopoulou O, Abs R, et al. Optimalization and cost management of lanreotide-Autogel therapy in acromegaly. Eur J Endocrinol. 2007;571-577.


Acromegaly. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated May 9, 2014. Accessed June 4, 2014.


Acromegaly treatment consensus workshop participants: guidelines for acromegaly management. J Clin Endocrinol Metab. 2002; 87:4054-4058.


Cook DM. AACE Acromegaly Guidelines Taskforce. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of acromegaly. Endoc Pract. 2004;10:213-225.


Glustina A, Barkan A, Casanueva FF, et al. Criteria for cure of acromegaly: a consensus statement. J Clin Endocrinol Metab. 2000;85:526-529.


Katznelson L, Atkinson JL, Cook DM, Ezzat SZ, Hamrahian AH, Miller KK. American association of clinical endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of acromegaly - 2011 update: executive summary. Endocr Pract. 2011;17(4):636-646.


Melmed S. Medical progress: acromegaly. N Engl J Med. 2006;355:2558-2573.


Paisley AN, Trainer PJ. Medical treatment in acromegaly. Curr Opin Pharmacol. 2003;3:672-677.


Sherlock M, Woods C, Sheppard MC. Medical therapy in acromegaly. Nat Rev Endocrinol. 2011;7(5):291-300.


Trainer PJ, Drake WM, Katzneison L, et al. Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant. N Engl J Med. 2000; 342:1171-1177.

 

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