Munson Health
 
Precocious Puberty

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by McCoy K

(Precocious Sexual Development, Premature Puberty)

 

Causes

Puberty is a complex process of brain, body, and hormonal development. If your child begins puberty at an early age, it may just be a variation in the range of what is considered normal.
In about 25%-75% of affected boys, this condition is due to underlying medical conditions. However, for many girls and some boys there is no known cause.
In rare cases, precocious puberty may be caused by conditions such as:
  • Congenital adrenal hyperplasia
  • McCune-Albright syndrome
  • Tumors or disorders of the testicles, ovaries, or adrenal gland
  • hCG-secreting tumors
  • Hypothalamic hamartoma (HH)—a rare benign brain tumor near the hypothalamus
  • Severe hypothyroidism
Other causes:
  • Acute head trauma
  • Central nervous system infection
  • Radiation treatment
  • Taking estrogen in girls
  • Taking male sex hormones in boys
Abnormalities in Adrenal Glands or Hypothalamus May Lead to Precocious Puberty
Kidney and adrenal
Copyright © Nucleus Medical Media, Inc.
Hypothalamus
Copyright © Nucleus Medical Media, Inc.
 

RESOURCES

National Institute of Child Health and Human Development
http://www.nichd.nih.gov

Nemours Foundation
http://www.kidshealth.org

 

CANADIAN RESOURCES

Health Canada
http://www.hc-sc.gc.ca

The Hospital for Sick Children
http://www.aboutkidshealth.ca

 

References


Baron J, Barnes K. Regulation of skeletal growth. National Institute of Child Health and Human Development: Annual report of the Division of Intramural Research; 2004. Accessed June 27, 2007.


Blondell RD, Foster MB, Kamlesh CD. Disorders of puberty. Am Fam Physician. 1999 Jul 1;60(1):209-218. Available at: http://www.aafp.org/afp/990700ap/209.html. Accessed July 16, 2013.


Cesario SK, Hughes LA. Precocious puberty: a comprehensive review of literature. J Ob Gyn Neonatal Nurs. 2007;36:263-274.


Himes JH, Obarzanek E, et al. Early sexual maturation, body composition, and obesity in African-American girls. Obesity Research. 2004;12:64S-72S.


Papathanasiou A, Hadjiathanasiou C. Precocious puberty. Ped Endocr Rev. 2006;3:182-187.


Precocious puberty. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated July 3, 2013. Accessed July 16, 2013.


Puberty and precocious puberty. National Institute of Child Health and Human Development website. Available at: http://www.nichd.nih.gov/health/topics/puberty/Pages/default.aspx. Updated April 3, 2013. Accessed July 16, 2013.


VN Brito, AC Latronico, et al. Update on the etiology, diagnosis and therapeutic management of sexual precocity. Arq Bras Endrocrinol Metab. 2008; 52(1):18-31.


Wang Y. Is obesity associated with early sexual maturation? A comparison of the association in American boys versus girls. Pediatrics. 2002;110:903-910.


12/13/2010 DynaMed's Systematic Literature Surveillance https://dynamed.ebscohost.com/about/about-us: Biro FM, Galvez MP, Greenspan LC, et al. Pubertal assessment method and baseline characteristics in a mixed longitudinal study of girls. Pediatrics. 2010;126(3):e583-590.

 

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