Munson Health
Perinatal Asphyxia

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(Hypoxic Ischemic Encephalopathy; HIE; Cerebral Hypoxia)



Brain Injury Association of America

National Institute of Neurological Disorders and Stroke



Health Canada

Ontario Brain Injury Association



Birth asphyxia and hypoxic ischemic encephalopathy (HIE). EBSCO PEMSoft website. Available at: Accessed February 25, 2013.

Brain injury secondary to carotid intervention [review]. J Endovasc Ther . 2007;14:219-231.

Edwards AD. The discovery of hypothermic neural rescue therapy for peri-natal hypoxic-ischemic encephalopathy. Semin Pediatr neurol . 2009;16(4):200-206.

Harrington DJ, Redman CW, Mouldan M, Greenwood CE. The long-term outcome in surviving infants with Apgar zero at 10 minutes: a systematic review of the literature and hospital-based cohort [review]. Am J Obstet Gynecol . 2007;196:463.e1-5.

Hemphill J, Smith W. Neurologic critical care, including hypoxic-ischemic encephalopathy and subarachnoid hemorrhage. In: Fauci AS, Braunwald E, Kasper DL, et al. Harrison's Principles of Internal Medicine . 17th ed. New York, NY: McGraw-Hill; 2005: chap 269.

Hypoxic ischemic encephalopathy (HIE). Neurographics website. Available at: Accessed February 19, 2013.

Itoo BA, Al-Hawsawi ZM, Khan AH. Hypoxic ischemic encephalopathy. Incidence and risk factors in North Western Saudi Arabia. Saudi Medical Journal . 2003;24:147-153.

Puohit D, Silverstein S. Perinatal hypoxic-ischemic encephalopathy. In: Gilman S, ed. MedLink Neurology . San Diego, CA: MedLink.

Schulzke SM, Rao S, Patole SK. A systematic review of cooling for neuroprotection in neonates with hypoxic ischemic encephalopathy-are we there yet? BMC Pediatr . 2007;7:30.

8/11/2014 DynaMed's Systematic Literature Surveillance Azzopardi D, Strohm B, et al. Effects of hypothermia for perinatal asphyxia on childhood outcomes. N Engl J Med. 2014;371(2):140-149.


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