Munson Health
 
Charcot-Marie-Tooth Disease

Back to Document

by Badash M

(Hereditary Motor and Sensory Neuropathies; HMSNs)

 

Symptoms

Usually, symptoms first appear in children and young adults. The first sign of CMT is often a high arched foot or difficulty walking. Other symptoms may include:
  • Hammer toes
  • High arched heels
  • Decreased sensation in the feet and legs
  • Muscle cramping in legs and forearms
  • Flexed toes
  • Difficulty holding the foot up in a horizontal position
  • Frequent sprained ankles and ankle fractures
  • Problems with balance
  • Muscle weakness in the lower extremities—can spread to the upper extremities later in life
  • Reduced ability to detect hot and cold, vibration, and position
  • Difficulty writing, fastening buttons and zippers, and handling small objects
  • Delay in learning how to walk—Type III
 

RESOURCES

Charcot-Marie-Tooth Association
http://www.charcot-marie-tooth.org

National Institute of Neurological Disorders and Stroke
http://www.ninds.nih.gov

 

CANADIAN RESOURCES

About Kids Health
http://www.aboutkidshealth.ca

Health Canada
http://www.hc-sc.gc.ca

 

References


Nave KA, Sereda MW, et al. Mechanisms of disease: inherited demyelinating neuropathies—from basic to clinical research. Nat Clin Pract Neurol. 2007;3:453-464.


Pareyson D. Differential diagnosis of Charcot-Marie-Tooth disease and related neuropathies. Neurol Sci. 2004;25:72-82.


Peroneal muscular atrophy. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php. Updated Updated November 7, 2012. Accessed July 24, 2013.


Reilly MM, Murphy SM, et al. Charcot-Marie-Tooth disease. J Periph Nerv Syst. 2011;16(1):1-14.

 

Revision Information