Munson Health
 
Addison's Disease

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by Badash M

(Adrenal Insufficiency; Adrenocortical Hypofunction; Chronic Adrenocortical Insufficiency; Hypoadrenalism)

 

Causes

Addison's disease is the result of gradual damage to the outer layer of the adrenal gland. This damage may be caused by:
 

Risk Factors

Factors that increase your chance of getting Addison's disease include:
 

Symptoms

Symptoms may include:
A severe complication of Addison's disease is the Addisonian or adrenal crisis . Adrenal crisis is a life threatening disorder, its symptoms include:
  • High or low body temperature
  • Severe abdominal, back, or leg pain
  • Fainting
  • Severe dehydration
  • Severe nausea, vomiting, and diarrhea
  • Bluish skin color
  • Muscle weakness
 

RESOURCES

The Adrenoleukodystrophy Foundation
http://www.aldfoundation.org

National Adrenal Diseases Foundation
http://www.nadf.us

 

CANADIAN RESOURCES

The Canadian Addison Society
http://www.addisonsociety.ca

Health Canada
http://www.hc-sc.gc.ca

 

References


Adrenal insufficiency and Addison's disease. National Endocrine and Metabolic Diseases Information Service website. Available at: http://endocrine.niddk.nih.gov/pubs/addison/addison.aspx. Updated May 14, 2014. Accessed June 4, 2014.


Adrenal insufficiency in adults. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated December 16, 2013. Accessed June 4, 2014.


Arlt W, Allolio B. Adrenal insufficiency. Lancet. 2003;361(9372):1881-1893.


Dorin RI, Qualls CR, Crapo LM. Diagnosis of adrenal insufficiency. Ann Int Med. 2003;138:3:194-214.


Hahner S, Allolio B. Therapeutic management of adrenal insufficiency. Best Pract Res Clin Endocrinol Metab. 2009;23(2):167-79.


Salvatori R. Adrenal insufficiency. JAMA. 2005;294:2481-2488.


Ten S, New M, Maclaren N. Clinical Review 130: Addison's disease. J Clin Endo Metabol. 2001;86:2909-2922.


Thomas Z, Fraser GL. An update on the diagnosis of adrenal insufficiency and the use of corticotherapy in critical illness. Ann Pharmather. 2007;41:1456-65.


Wallace I, Cunningham S, Lindsay J. The diagnosis and investigation of adrenal insufficiency in adults. Ann Clin Biochem. 2009;46(Pt 5):351-367.

 

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