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Addison's Disease

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by Badash M

(Adrenal Insufficiency; Adrenocortical Hypofunction; Chronic Adrenocortical Insufficiency; Hypoadrenalism)

 

Causes

Addison's disease is the result of gradual damage to the outer layer of the adrenal gland. This damage may be caused by:
 

Risk Factors

Factors that increase your chance of getting Addison's disease include:
 

Symptoms

Symptoms may include:
A severe complication of Addison's disease is the Addisonian or adrenal crisis . Adrenal crisis is a life threatening disorder, its symptoms include:
  • Severe abdominal, back, or leg pain
  • Fainting
  • Severe low blood pressure
  • Severe dehydration
  • Severe nausea, vomiting, and diarrhea
  • Low blood sugar
  • Generalized muscle weakness
 

RESOURCES

The Adrenoleukodystrophy Foundation
http://www.aldfoundation.org

National Adrenal Diseases Foundation
http://www.nadf.us

 

CANADIAN RESOURCES

The Canadian Addison Society
http://www.addisonsociety.ca

Health Canada
http://www.hc-sc.gc.ca

 

References


Addison's disease. National Institute of Diabetes and Digestive and Kidney Diseases website. Available at: http://www.niddk.nih.gov/health/endo/pubs/addison/addison.htm . Updated April 6, 2012. Accessed June 25, 2013.


Adrenocortical insufficiency. EBSCO DynaMed website. Available at: https://dynamed.ebscohost.com/about/about-us . Updated May 29, 2013. Accessed June 25, 2013.


Arlt W, Allolio B. Adrenal insufficiency. Lancet . 2003;361(9372):1881-1893.


Dorin RI, Qualls CR, Crapo LM. Diagnosis of adrenal insufficiency. Ann Int Med . 2003;138:3:194-214.


Hahner S, Allolio B. Therapeutic management of adrenal insufficiency. Best Pract Res Clin Endocrinol Metab . 2009;23(2):167-79.


Salvatori R. Adrenal insufficiency. JAMA . 2005;294:2481-2488.


Ten S, New M, Maclaren N. Clinical Review 130: Addison's disease. J Clin Endo Metabol . 2001;86:2909-2922.


Thomas Z, Fraser GL. An update on the diagnosis of adrenal insufficiency and the use of corticotherapy in critical illness. Ann Pharmather . 2007;41:1456-65.


Wallace I, Cunningham S, Lindsay J. The diagnosis and investigation of adrenal insufficiency in adults. Ann Clin Biochem . 2009;46(Pt 5):351-367.

 

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