Munson Health
 
Medications for Benign Prostatic Hyperplasia (BPH)

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by Polsdorfer R
 
The information provided here is meant to give you a general idea about each of the medications listed below. Only the most general side effects are included, so ask your doctor if you need to take any special precautions. Use each of these medications as recommended by your doctor, or according to the instructions provided. If you have further questions about usage or side effects, contact your doctor.
A couple of medications are available to treat less advanced cases of BPH. One type relaxes the smooth muscle in the prostate; the other kind decreases the amount of hormone stimulating prostate growth. Symptoms of BPH can also be relieved by antimuscarinics, a group of drugs that work to relax bladder contractions.

Prescription medications

  • Prazosin (Minipress)
  • Doxazosin (Cardura)
  • Terazosin (Hytrin)
  • Tamsulosin (Flomax)
  • Alfuzosin (Uroxatral)
  • Silodosin (Rapaflo)
  • Finasteride (Proscar)
  • Dutasteride (Avodart)
  • Oxybutynin (Ditropan, Oxytrol)
  • Solifenacin (Vesicare)
  • Tolterodine (Detrol)
  • Darifenacin (Enablex)
  • Trospium (Sanctura)
  • Fesoterodine (Toviaz)
  • Tadalafil (Cialis)
  • Dutasteride and tamsulosin (Jalyn)
  Phosphodiesterase-5 Enzyme Inhibitor
Tadalafil [Cialis]
Tadalafil is a medication that is often prescribed to treat the symptoms of erectile dysfunction , also known as impotence. The Food and Drug Administration (FDA) has recently approved Tadalafil as a treatment for BPH, as well. The medication can reduce symptoms, like difficulty starting to urinate, weak urination stream, and the urge to urinate frequently.
Potential side effects of Tadalafil include flushing, headache, stomach upset, back pain, and congestion.
Note: You should not take Tadalafil if you are also taking nitrates, because your blood pressure may become dangerously low. Also, Tadalafil should not be taken in combination with alpha-blockers.
 

References


Benign prostatic hypertrophy (BPH). EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php. Updated July 25, 2013. Accessed August 22, 2013.


BPH. National Kidney Urologic Diseases Information Clearinghouse website. Available at: http://kidney.niddk.nih.gov/kudiseases/pubs/prostateenlargement. Updated March 23, 2012. Accessed August 22, 2013.


Greco KA, McVary KT. The role of combination medical therapy in benign prostatic hyperplasia. Int J Impot Res. 2008 Dec;20 Suppl 3:S33-43.


Marks LS, Gittelman MC, et al. Rapid efficacy of the highly selective alpha1A-adrenoceptor antagonist silodosin in men with signs and symptoms of benign prostatic hyperplasia: pooled results of 2 phase 3 studies. J Urol. 2009 Jun;181(6):2634-2640. Epub 2009 Apr 16.


Medical Management of BPH. Urology Care Foundation website. Available at: http://www.urologyhealth.org/urology/index.cfm?article=1. Updated January 2011. Accessed August 22, 2013.


Roehrborn CG, Siami P, et al. CombAT Study Group. The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4-year results from the CombAT study. Eur Urol. 2010 Jan;57(1):123-131. Epub 2009 Sep 19.


1/4/2011 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php: Tacklind J, Fink H, et al. Finasteride for benign prostatic hyperplasia. Cochrane Database Syst Rev. 2010;(10):CD006015.


10/14/2011 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/: US Food and Drug Administration. FDA approves Cialis to treat benign prostatic hyperplasia. US Food and Drug Administration website. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm274642.htm. Updated October 6, 2011. Accessed October 14, 2011.

 

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