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Conditions InDepth: Peripheral Artery Disease (PAD)

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by Polsdorfer R
 

PAD Causes

Atherosclerosis is the most common cause of PAD. Atherosclerosis is the gradual build up of a plaque, on the walls of the blood vessels. This plaque is a waxy substance made of fats and other material in the blood that stick to the walls. It can also be made of scar tissue or fibers that were needed to repair damage to blood vessel walls. Overtime this plaque grows by trapping other substances in the blood. Substances in the blood like LDL "bad" cholesterol and glucose are more easily trapped in the formed plaque. As the plaque growth continues, the blood vessel opening will narrow making blood flow more difficult.
Factors that can damage blood vessels and contribute to atherosclerosis include:
  • Smoking—chemicals from cigarette smoke can irritate blood vessel walls and make deposits in the walls of blood vessels
  • High cholesterol—"bad" cholesterol can stick to and irritate the walls of the blood vessels
  • High blood pressure—causes turbulent blood flow that can injure the walls of blood vessels
  • Diabetes—excess glucose in the blood can contribute to plaque build up in blood vessels
  • Radiation therapy
Atherosclerosis
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What are the risk factors for peripheral artery disease?What are the symptoms of peripheral artery disease?How is peripheral artery disease diagnosed?What are the treatments for peripheral artery disease?Are there screening tests for peripheral artery disease?How can I reduce my risk of peripheral artery disease?What questions should I ask my doctor?What is it like to live with peripheral artery disease?Where can I get more information about peripheral artery disease?
 

References


About peripheral artery disease (PAD). American Heart Association website. Available at: http://www.heart.org/HEARTORG/Conditions/More/PeripheralArteryDisease/About-Peripheral-Artery-Disease-PAD%5FUCM%5F301301%5FArticle.jsp. Updated September 13, 2012. Accessed June 20, 2014.


Hills AJ, Shalhoub J, et al. Peripheral arterial disease. Br J Hosp Med (Lond). 2009;70(10):560-565.


Jurado JA, Bashir R, et al. Radiation-induced peripheral artery disease. Catheter Cardiovasc Interv. 2008;72(4):563-568.


Peripheral arterial disease (PAD) of lower extremities. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated June 13, 2014. Accessed June 20, 2014.


What causes peripheral arterial disease? National Heart, Lung, and Blood Institute website. Available at: http://www.nhlbi.nih.gov/health/health-topics/topics/pad/causes.html. Updated June 2, 2014. Accessed June 20, 2014.


What is peripheral arterial disease? National Heart, Lung, and Blood Institute website. Available at: http://www.nhlbi.nih.gov/health/health-topics/topics/pad. Updated June 2, 2014. Accessed June 20, 2014.

 

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