Munson Health
Medications for Post-traumatic Stress Disorder

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by Scholten A
The information provided here is meant to give you a general idea about each of the medications listed below. Only the most general side effects are included. Ask your doctor if you need to take any special safety measures. Use each of these medications as recommended by your doctor or according to the instructions provided. If you have further questions about usage or side effects, contact your doctor.
Studies have shown that certain medications can help to ease symptoms of anxiety, depression, and insomnia in people with PTSD. More research is being done on drugs that target the biological changes of PTSD.

Prescription Medications

  • Zoloft
  • Paroxetine
  • Fluoxetine
  • Propranolol


American Psychiatric Association: Guideline Watch (March 2009): Practice guideline for the treatment of patients with acute stress disorder and posttraumatic stress disorder. Focus. 2009; 7.

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Post-traumatic stress disorder (PTSD). EBSCO DynaMed website. Available at Updated October 5, 2012. Accessed November 25, 2012.

Moore DP, Jefferson JW. Handbook of Medical Psychiatry. 2nd ed. Philadelphia, PA: Elsevier Mosby; 2004.

Stern, TA et al. Massachusetts General Hospital Comprehensive Clinical Psychiatry. 1st ed. Philadelphia: Mosby Elsevier, 2008.

Treatment of anxiety disorders. National Institute of Mental Health website. Available at: Accessed November 25, 2012.

USP DI. 21st ed. Micromedex; 2001.

What medications are used to treat anxiety disorders? National Institute of Mental Health website. Available at: Accessed November 25, 2012.

Raskind, MA et al. A trial of prazosin for combat trauma PTSD with nightmares in active-duty soldiers returned from Iraq and Afghanistan. Am J Psychiatry. 2013 Sep 1;170(9):1003-10.

2/18/2011 DynaMed's Systematic Literature Surveillance Serretti A, Mandelli L. Antidepressants and body weight: a comprehensive review and meta-analysis. J Clin Psychiatry. 2010;71(10):1259-1272.


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