Munson Health
Medications for Temporomandibular Disorders (TMD)

Back to Document

by Carson-DeWitt R
There are no medicines that are specifically designed to treat TMD. However, if you are having a lot of pain and discomfort, your doctor might recommend a pain reliever, muscle relaxant, or a type of antidepressant that is used to treat chronic pain. In severe cases, your doctor or dentist may recommend a shot of a steroid into the joint to decrease inflammation and relieve pain. These medicines are usually used for very brief periods of time. Check with your doctor to determine exactly how long you should be using these types of medicines.

Prescription Medications

  • Diazepam
  • Alprazolam
  • Clonazepam
  • Amitriptyline
  • Clomipramine
  • Desipramine
  • Imipramine
  • Nortriptyline (Aventyl, Pamelor)

Over-the-Counter Medications



Mujakperuo HR, Watson M, et al. Pharmacological interventions for pain in patients with temporomandibular disorders. Cochrane Database Syst Rev . 2010 Oct 6;(10):CD004715.

Siccoli MM. Facial pain: a clinical differential diagnosis. Lancet Neurology . 2006;5:257-267.

Temporomandibular joint (TMJ) dysfunction. EBSCO DynaMed website. Available at: . Updated November 27, 2012. Accessed April 5, 2013.

TMJ. American Academy of Otolaryngology—Head and Neck Surgery website. Available at: . Updated December 2010. Accessed April 5, 2013.

TMJ. American Dental Association Mouth Healthy website. Available at: . Accessed April 5, 2013.

TMJ (temporomandibular joint and muscle disorders). National Institute of Dental and Craniofacial Research website. Available at: . Updated March 21, 2013. Accessed April 5, 2013.

2/18/2011 DynaMed's Systematic Literature Surveillance : Serretti A, Mandelli L. Antidepressants and body weight: a comprehensive review and meta-analysis. J Clin Psychiatry . 2010;71(10):1259-1272.


Revision Information