Munson Health
 
Tardive Dyskinesia

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by Wood D

(TD)

 

Treatment

To treat TD, your doctor may:
Symptoms may decrease over time even if you continue to take the neuroleptic drug. Younger people tend to do better.

Medication

Some medications may help decrease symptoms, such as:
  • Trihexyphenidyl
  • Reserpine
  • Propranolol
  • Clonidine
  • Baclofen
  • Sedatives, such as:
    • Diazepam
    • Clonazepam
  • Antiseizure drugs, such as:
    • Valproic acid
    • Levetiracetam
  • Antipsychotic drugs that may help with movement disorders, such as sulpiride, oxypertine, tiapride and other medication, such as L-dopa, which is a type of amino acid.
  • Melatonin
  • Diphenhydramine

Surgery

Deep Brain Stimulation (DBS) is being evaluated for the treatment of TD.
 

RESOURCES

National Alliance on Mental Illness
http://www.nami.org

National Institute of Neurological Disorders and Stroke
http://www.ninds.nih.gov

 

CANADIAN RESOURCES

Canadian Mental Health Association
http://www.ontario.cmha.ca

Mental Health Canada
http://www.mentalhealthcanada.com

 

References


Bai YM, Yu SC, Lin CC. Risperidone for severe tardive dyskinesia: a 12-week randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2003;64:1342-1348.


Damier P. Drug-induced dyskinesias. Curr Opin Neurol. 2009;22(4):394-399.


Kinon BJ, Jeste DV, Kollack-Walker S, Stauffer V, Liu-Seifert H. Olanzapine treatment for tardive dyskinesia in schizophrenia patients: a prospective clinical trial with patients randomized to blinded dose reduction periods. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28:985-996.


McGrath JJ, Soares KV. Neuroleptic reduction and/or cessation and neuroleptics as specific treatments for tardive dyskinesia. Cochrane Database Syst Rev. 2006;CD000459.


Meco G, Fabrizio E, Epifanio A, et al. Levetiracetam in tardive dyskinesia. Clin Neuropharmacol. 2006;29:265-268.


Pham DQ, Plakogiannis R. Vitamin E supplementation in Alzheimer’s disease, Parkinson’s disease, tardive dyskinesia, and cataract: part 2. Ann Pharmacother. 2005;39(12):2065-72.


Sachdev PS. The current status of tardive dyskinesia. Australian and New Zealand Journal of Psychiatry. 2000;34:355-369.


Soares KV, McGrath JJ. The treatment of tardive dyskinesia: a systematic review and meta-analysis. Izophr Res. 1999;39(1):1-16.


Tardive dyskinesia. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated November 23, 2011. Accessed July 29, 2013.


Tardive dyskinesia. National Alliance on Mental Illness website. Available at: http://www.nami.org/Content/ContentGroups/Helpline1/Tardive%5FDyskinesia.htm. Updated September 2003. Accessed July 29, 2013.


Thema B, Srivastava V, Tiwari AK. Genetic underpinnings of tardive dyskinesias: passing the baton to pharmacogenetics. Pharmacogenomics. 2008;9:1285-1306.

 

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