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Risk Factors

Factors that may interfere with hormones and lead to hypercalcemia include:
Factors that may increase the amount of calcium in the body include:
  • Excess vitamin D and/or vitamin A supplements—increases absorption of calcium
  • Certain medications, including diuretics and calcium-containing antacids
  • Certain diseases associated with inflammation such as sarcoidosis, berylliosis, or tuberculosis
  • Hodgkin lymphoma
Other factors that may increase your risk of hypercalcemia include:
  • Excess vitamin D—causes release of calcium from the bones into the blood
  • Cancer or treatment for cancer—causes release of calcium from damaged cells
  • Genetic disorders
  • Phosphate deficiency in newborns
  • Kidney disease or failure—cannot get rid of calcium


Symptoms may include:


American Academy of Family Physicians

American Association of Clinical Endocrinologists



The Canadian Society of Endocrinology and Metabolism

Health Canada



Carroll M, Schade D. A practical approach to hypercalcemia. Am Fam Physician. 2003 May 1;67(9):1959-1966.

Hypercalcemia. EBSCO DynaMed website. Available at: Updated November 13, 2013. Accessed January 8, 2013.

Hypercalcaemia. Patient UK website. Available at: Updated March 3, 2014. Accessed January 8, 2013.


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