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Anemia of Chronic Disease

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by McCarthy AA

(Anemia of Inflammation; Hypoferremia of Inflammatory Disease; ACD)

 

Treatment

With ACD, if the underlying disease causing it is found and treated, the anemia may improve or clear on its own. Iron supplements and vitamins are generally not effective.
For severe cases of ACD, blood transfusions may be necessary. Another treatment is to give erythropoiesis-stimulating agents (ESAs), which help stimulate growth of new red blood cells. These drugs do have risks that are important to consider before using them. There is some evidence that ESAs may shorten survival in cancer patients.
 

RESOURCES

Iron Disorders Institute
http://www.irondisorders.org

National Heart, Lung, and Blood Institute
http://www.nhlbi.nih.gov

 

CANADIAN RESOURCES

Canadian Cancer Society
http://www.cancer.ca

Health Canada
http://www.hc-sc.gc.ca

 

References


Beutler E. Unlocking the mysteries of iron homeostasis and of the anemia of chronic disease: is hepcidin the key? Blood. 2003;102:775.


Weiss G, Goodnough, LT. Anemia of chronic disease. NEJM. 2005;352:1011-1023.


What is anemia? National Heart Lung and Blood Institute website. Available at: http://www.nhlbi.nih.gov/health/health-topics/topics/anemia/. Updated May 18, 2012. Accessed August 19, 2014.


3/12/2008 DynaMed Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Bennett CL, Silver SM, Djulbegovic B, et al. Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia. JAMA. 2008;299:914-924.


9/2/2009 DynaMed Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Bohlius J, Schmidlin K, Brillant C, et al. Erythropoietin or Darbepoetin for patients with cancer—meta-analysis based on individual patient data. Cochrane Database Syst Rev. 2009;(3):CD007303.

 

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