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Pernicious Anemia

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by Kahn M

(Juvenile Pernicious Anemia; Congenital Pernicious Anemia)

 

Causes

There are many possible causes of pernicious anemia. Some are listed below.
  • Atrophic gastritis (inflammation of the stomach)
  • Removal of all or part of the stomach
  • Immune system reaction to:
    • Intrinsic factor—a protein necessary for vitamin B12 absorption
    • Cells that produce both intrinsic factor and hydrochloric acid in the stomach
  • Genetics
 

Symptoms

The symptoms of pernicious anemia can vary from person-to-person. Symptoms may change or worsen over time. If you experience any of these symptoms, do not assume it is due to pernicious anemia. These symptoms may be caused by other health conditions. If you experience any one of them, see your physician. Symptoms can include:
 

RESOURCES

Family Doctor
http://familydoctor.org/

National Institutes of Health Office of Dietary Supplements
http://ods.od.nih.gov/index.aspx/

 

CANADIAN RESOURCES

Health Canada
http://www.hc-sc.gc.ca/index-eng.php/

Public Health Agency of Canada
http://www.phac-aspc.gc.ca/chn-rcs/index-eng.php/

 

References


Beers MH, Berkow R, eds. The Merck Manual of Diagnosis and Therapy . 17th ed. Whitehouse Station, NJ: Merck Research Laboratories; 1999.


Beers MH, Porter RS, Jones TV, eds. The Merck Manual of Diagnosis and Therapy . 18th ed. Whitehouse Station, NJ: Merck Research Laboratories; 2006.


DynaMed Editorial Team. Pernicioius anemia. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated April 27, 2010. Accessed November 10, 2010.


Escott-Stump S. Nutrition and Diagnosis-Related Care . 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2002.


Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, eds. Harrison’s Principles of Internal Medicine . 16th ed. New York, NY: McGraw-Hill Companies, Inc; 2005.


Mahan LK, Escott-Stump S, eds. Krause’s Food, Nutrition and Diet Therapy . 10th ed. Philadelphia, PA: WB Saunders Company; 2000.


Mahan LK, Escott-Stump S, eds. Krause’s Food, Nutrition and Diet Therapy . 11th ed. Philadelphia, PA: WB Saunders Company; 2003.


Morrison G, Hark L, eds. Medical Nutrition and Disease . 2nd ed. Malden, MA: Blackwell Science; 1999.


Whitney EN, Rolfes SR. Understanding Nutrition . 8th ed. Belmont, CA: West/Wadsworth; 1999.


Whitney EN, Rolfes SR. Understanding Nutrition . 9th ed. Belmont, CA: West/Wadsworth; 2002.

 

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